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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbations. Design: A systematic review and meta-analysis, au-roids.com review. Patients: A total of 2932 patients were included (mean age, 67, platinum anabolics australia review.7 years; 34, platinum anabolics australia review.0% women), who met the inclusion criteria for this review and meta-analysis Intervention: Cohort studies or randomized control trials (RCTs), with adequate treatment arm length, were included, including trials of inhaled glucocorticoid as a nonpharmacologic treatment. Data were extracted and pooled by using data abstraction methods. Main Outcome Measures: The primary outcome measure is the difference in mean change from baseline in the mean change from baseline in the percent of patients who respond to inhaled corticosteroids versus control therapy versus placebo (the Primary Outcome Effect), buying steroids online in australia. Results: After adjustment for differences in primary outcome between groups, an inhaled corticosteroid treatment (1,000 or 2,000 mg twice daily; placebo) with more effect on the Primary Outcome Effect than a placebo showed statistically significantly less improvement of the Primary Outcome Effect of the patients compared with the placebo group (relative risk (RR) = 0, review au-roids.com.80, 95% confidence interval (CI) = 0, review au-roids.com.67 to 0, review au-roids.com.97; P = , review au-roids.com.011), review au-roids.com. In the RCTs for inhaled corticosteroids (100, 150, or 200 mg twice daily), the improvement in the Primary Outcome Effect was similar for both groups. The primary outcome measures for the inhaled corticosteroids were not significantly different than those for placebo in any of the RCTs but were significantly related in one of the RCTs. Conclusion: When considering efficacy as an independent outcome of inhaled corticosteroids, these trials show a smaller effect than placebo. References 1 Mazzocchi P Piacentini A Sannone A Effect of inhalation of corticosteroids on CO2 production in human airway , buying steroids online in australia. Metabolism 1991 ; 33 : 1721 – 8 , top steroids online australia. 2 Lander KL Anderson ML Crippa LV Vollenweider CA Kuczmarski JD A randomized clinical trial of inhaled glucocorticoids for COPD exacerbations . Ann Intern Med 1993 ; 125 : 479 – 84 .
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